2017 Fiscal Year Final Research Report
Analysis of roles of neuromedin U in experimental autoimmune uveitis
| Project/Area Number |
15K10896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木村 和博 山口大学, 大学院医学系研究科, 教授 (60335255)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ぶどう膜炎 / Tリンパ球 / 網膜色素上皮細胞 / 神経ペプチド |
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| Outline of Final Research Achievements |
Neuromedin U (NmU)－/－ and NmU+/+ mice were immunized with human interphotoreceptor retinoid binding protein peptide 1-20 (IRBP) to induce EAU. Histological analysis revealed a significant induction of cellular infiltration into the retina in NmU－/－ mice on day 21, correlated with increased gene expression of proinflammatory cytokines, including interferon-γ and interleukin-17. On the other hand, Th1 and Th17 cell responses were reduced in NmU－/－ mice. Immunohistochemical analysis showed that NmU receptor 1 was expressed in retinal pigment epithelial (RPE) and ciliary epithelial cells, and Muller cells, whereas Nmu receptor 2 in RPE and ciliary epithelial cells. These results suggested that NmU provides EAU restraint through participation of RPE in the eye.
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| Free Research Field |
眼科学
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