2017 Fiscal Year Final Research Report
Development of a neuroprotective therapy for retinitis pigmentosa based on the iPS research
| Project/Area Number |
15K10903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
Ozawa Yoko 慶應義塾大学, 医学部(信濃町), 専任講師 (90265885)
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| Research Collaborator |
KAWASHIMA Hirohiko
OSADA Hideto
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 網膜 / 神経保護 / iPS細胞 |
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| Outline of Final Research Achievements |
We have previously developed induced-pluripotent stem cell (iPSC) lines from somatic cells of a patient with retinitis pigmentosa, which is a hereditary disease caused by gene mutation. The iPS cells were differentiated into retinal cells to reveal the mechanism of the disease in vitro, and the study proposed candidate therapeutic drugs for neuroprotection. In the current study, we treated the mouse model of retinitis pigmentosa (P23H rhodopsin knock-in mice) with one of the candidate drugs to analyze the protective effects in vivo.
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| Free Research Field |
眼科学
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