Research for the development of medical treatment of adenoviral ocular infection and its introduction in clinical practice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10911
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Fukuoka University
• Principal Investigator: Uchio Eiichi 福岡大学, 医学部, 教授 (70232840)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アデノウイルス / 抗ウイルス薬 / 遺伝子系統解析 / 流行性角結膜炎

Outline of Final Research Achievements

Adenovirus causes epidemic keratoconjunctivitis and it has induced large epidemic every year. New types have appeared recently, and ocular manifestations have changed. Antiviral activity of stavudine was evaluated in several types in vitro. It was shown that stavudine had dose-dependent inhibitory effect on novel types 53, 54 and 56 similarly with type 4 and 64 of conventional types indicating that stavudine is effective against novel adenovirus types that are currently causing epidemics. From the clinical analysis of adenoviral conjunctivitis caused by type 54, it was shown that clinical score of younger cases was significantly more serious than that of adult cases, indicating age specific clinical characteristics leading to clinical insight.

Free Research Field

眼科学