Induction of Muller glia-derived retinal regeneration by expressing regeneration promoting genes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10914
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター)
• Principal Investigator: Okamoto Akiko (須賀) 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 (70450400)
• Co-Investigator(Renkei-kenkyūsha): IWATA Takeshi 独立行政法人国立病院機構, 東京医療センター臨床研究センター, 部長 (90374157)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 網膜 / グリア細胞 / 再生 / 変性モデル

Outline of Final Research Achievements

Recovery of visual function is a recent issue for regenerative medicine. Several methods, such as iPS cell-based retinal cell/tissue transplantation, recovery of visual function using channel Rhodopsin and artificial retinal implant, are in progress. On the other hand, retinal Muller glia is focused as an injury-induced retinal stem/progenitor cell in vertebrate species. Regeneration of retinal neuronal cells from Muller glia has also been studied. In this study, we examined regeneration potential of mouse Muller glia by inducing candidate regeneration promoting genes by using adeno-associated virus transfection.

Free Research Field

網膜　発生生物学　再生　分子生物学