2017 Fiscal Year Final Research Report
In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patients
| Project/Area Number |
15K10994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平山 令明 東海大学, 先進生命科学研究所, 教授 (70238393)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | IL-15 / In silico screening |
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| Outline of Final Research Achievements |
Interleukin-15 (IL-15) is a cytokine that acts on NK cells and T cells and induces cell proliferation and activation. Evaluation of the effect on STAT5 phosphorylation of 15 compounds selected by in silico screening showed strong antagonistic (inhibitory) effect (inhibition rate 32%) with compound N43. In addition, weak inhibitory effect was observed for compounds N6, N15 and N35. In future, we aim to establish an evaluation system utilizing a sandwich ELISA method in the future.
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| Free Research Field |
救急医学
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