2017 Fiscal Year Final Research Report
Stem cell transplantation for vascular permeability and angiogenesis under surgical stress
| Project/Area Number |
15K10997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮部 浩道 藤田保健衛生大学, 医学部, 講師 (90398363)
野口 宏 愛知医科大学, 医学部, 教授 (20065569)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | MPO-DNA / 敗血症性ショック |
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| Outline of Final Research Achievements |
Aim: The objectives of this study were to investigate the correlations between plasma myeloperoxidase (MPO) conjugated-DNA level with degree of organ dysfunction, disease severity, and ICU mortality in septic shock patients. Results: On day 1, septic shock patients displayed a marked increase of plasma MPO-DNA level compared with the healthy volunteers. Plasma MPO-DNA levels were significantly decreased on days 3 and 7. The MPO-DNA level on 7th day was inversely correlated with both the mean arterial pressure and P/F ratio at 7th day. Negative correlation was observed between plasma MPO-DNA level on 1st day. Positive correlation was observed between plasma MPO-DNA level on 7th day and SOFA at 7th day . Using Wilcoxon signed-rank test the high MPO-DNA on 3rd day was found to be associated with the hospital mortality
Discussion: High MPO-DNA levels at 3rd and 7th days of septic shock patients are associated with the degree of organ dysfunction and hospital mortality.
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| Free Research Field |
救急集中治療
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