Functional roles of RhoT1 on repair of periodontal tissue

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nihon University (2017); Matsumoto Dental University (2015-2016)
• Principal Investigator: NINOMIYA Tadashi 日本大学, 歯学部, 准教授 (00360222)
• Co-Investigator(Kenkyū-buntansha): 小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617) ; 中村 浩彰 松本歯科大学, 歯学部, 教授 (50227930) ; 平賀 徹 松本歯科大学, 歯学部, 准教授 (70322170)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: RhoT1 / MSCs / 遊走能 / ミトコンドリア

Outline of Final Research Achievements

This study aimed to elucidate the functional role of mitochondrial Rho GTPase 1 (RhoT1), mitochondrial transporter factor, on the repair of periodontal tissue. RhoT1 expressed on mesenchymal stromal cells (MSCs) in periodontal ligament (PDL) and the level of its expression increased with stimulation of LPS and starvation state. In addition, damaged PDL MSCs were rescued by a transport of mitochondria from intact PDL MSCs and then were survived. These finding indicated that RhoT1 is important for restoring the damage of periodontal ligament cells.

Free Research Field

口腔解剖学