Analysis of cathepsin K inhibitor in murine jaw bone metastasis model of oral cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Saga University
• Principal Investigator: DANJO Atsushi 佐賀大学, 医学部, 准教授 (80452712)
• Co-Investigator(Kenkyū-buntansha): 山下 佳雄 佐賀大学, 医学部, 教授 (50322300) ; 下平 大治 佐賀大学, 医学部, 助教 (70594844) ; 鶴岡 祥子 佐賀大学, 医学部, 助教 (30612353) ; 井上 将成 佐賀大学, 医学部, 助教 (10720203) ; 後藤 昌昭 佐賀大学, その他部局等, 理事 (10145211)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔癌 / 顎骨浸潤 / カテプシンK / シスタチンC

Outline of Final Research Achievements

The treatment of local progress oral cancer with invasion to jawbone causes the functional disorder such as the deformity of the face or chewing ability, because of resection of the jaw bone. It is necessary to control the osteoclast functions which performs bone resorption to control jawbone invasion of oral cancer. We analyzed the effect of cathepsin K inhibitors which control bone resorption activities in osteoclasts using a jawbone invasion experimental model of oral squamous cell carcinoma in this study. The cathepsin K inhibitors did not affect the increase of osteoblasts and the osteoclasts by the in vitro experiment, but decreased the number of the human oral squamous cell carcinoma cells. There was the difference with the drug in the bone resorption inhibition effect of the cathepsin K inhibitors by the in vivo experiment, and the significant difference was not recognized.

Free Research Field

骨代謝、口腔癌