Elucidation of chronic inflammation exacerbation mechanism due to breakdown of endo-lysosomal proteolysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nagasaki University
• Principal Investigator: KADOWAKI Tomoko (筑波知子) 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70336080)
• Co-Investigator(Kenkyū-buntansha): 筑波 隆幸 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体応答 / エンドソーム / リソソーム / タンパク質分解 / 細胞内輸送

Outline of Final Research Achievements

Dental diseases such as periodontal disease, apical periodontitis, and Sjogren's syndrome often exhibit intractable chronic inflammation. The aim of this study is to show that abnormal endo-lysosomal proteolysis causes accumulation of internal irritants as a cause of chronic inflammation, which leads to prolonged and severe inflammation We found that deficiency of protease causes chronic inflammation and dysfunction of macrophage and adipose tissue differentiation. This study is not limited to chronic inflammation which accounts for the majority of oral diseases, and it clarifies one aspect of the chronic mechanism of systemic inflammation.

Free Research Field

歯科薬理学