Risk diagnosis of cerebral infarction by metagenomic and anti-ApoH antibody analysis in apical periodontitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Kato Satsuki 北海道医療大学, 歯学部, 講師 (50281283)
• Co-Investigator(Kenkyū-buntansha): 長澤 敏行 北海道医療大学, 歯学部, 教授 (90262203)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 根尖性歯周炎 / 動脈硬化症 / ApoH / TLRVYK / メタゲノム解析

Outline of Final Research Achievements

The aim of this study was to examine of ant-phospholipid antibody and TLRVYK antibody in apical periodontitis for systemic immune response by bacterial infection. Antibody titer of TLRVYK in systemic disease person were significant increase in comparison with healthy person. On the other hand, no differences of ant-phospholipid antibody between systemic disease person and healthy person. Next, we examined antibody titer of TLRVYK in apical periodontitis. Antibody titer of TLRVYK in apical periodontitis were higher than pulptitis. Furthermore, large number of bacteria detected in apical periodontitis by metagenomic analysis. Our results suggest that antibody titer of TLRVYK may be related with systemic immune response.

Free Research Field

歯周治療学