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2017 Fiscal Year Final Research Report

Development for primate periodontal tissue regenerative therapy by human iPS cells for xeno-free system

Research Project

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Project/Area Number 15K11221
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKeio University

Principal Investigator

Nakagawa Taneaki  慶應義塾大学, 医学部(信濃町), 教授 (00227745)

Co-Investigator(Kenkyū-buntansha) 森川 暁  慶應義塾大学, 医学部(信濃町), 講師 (00424169)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords歯周組織再生 / 神経堤細胞 / 間葉系幹細胞
Outline of Final Research Achievements

In this study, we realized the induction of neural crest cells, which was feeder-free, xeno-free iPS culture method. It was confirmed that neural crest cells existed in the periodontal ligament tissue of the mouse and some of them expressed PDGFRα and CD44 which are mesenchymal stem cell markers. This suggested that neural crest derived mesenchymal stem cells may be a potential source of cells for periodontal tissue regeneration therapy. In order to transplant these cells into real periodontal disease model mice, the disease model mice were prepared and evaluated. Periodontal disease induction model induced bone destruction by ligating 5-0 silk thread to mouse molar tooth. To confirm the technical reproducibility. Now, we have been preparing for transplantation.

Free Research Field

歯周病学

URL: 

Published: 2019-03-29  

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