Development of the tendon/ligament regenerative therapy utilizing human multipotent periodontal ligament stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: OKUBO Naoto 北海道大学, 薬学研究院, 特任助教 (00553207)
• Co-Investigator(Kenkyū-buntansha): 北川 善政 北海道大学, 歯学研究院, 教授 (00224957)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 再生医療 / 組織幹細胞 / 歯根膜幹細胞 / 靭帯再生 / 腱再生

Outline of Final Research Achievements

We previously reported that Periodontal ligament stem cells(PDLSCs) possess the capacity to construct three-dementional blood vessel structures in vitro and can differentiate into the activated fibloblasts called myofibloblasts, which is essential for wound healing process.
Here in this study, we report that PDLSCs can construct there-dementional ligament like structure in vitro to utilizing the collagen gel contractile activity which produced when PDLSCs differented into myofibrobrasts. This constructed ligament like structure not only has dense collagen fibers that parallel to one another but possess physical strength not to break off when it pilled both sides with fingers. These promising results suggesting that PDLSCs may provide a new therapeutic application for ligament/tendon regenerative therapy.

Free Research Field

医科・歯科再生医療