Investigation of new treatment management to try to prevent progression and exacerbation of oral mucositis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: Fumihiko Yoshino 神奈川歯科大学, 大学院歯学研究科, 准教授 (20308307)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口内炎 / 活性酸素 / 漢方薬 / 化学療法

Outline of Final Research Achievements

The aim of this research project is to analyze the effect on prevention / progression of oral mucositis accompanying cancer chemotherapy by antioxidant pretreatment. Alphal-glucosyl-hesperidin which is a water-soluble antioxidant substance and Chinese herbal medicine which is indicated for efficacy to oral mucositis, Hange-shashin-to/Inchinko-to/Oren-to indicated the satisfactory reactive oxygen species scavenging activity. In addition, exacerbation of oral mucositis was significantly suppressed by administering these antioxidants in vivo to experimental animals before prescribing chemotherapy. However, although the maximum area of oral mucositis caused as compared with the control was suppressed, shortening of the recovery period was not observed. From now on, it is necessary to combine with lipid-soluble antioxidants and others to aim for recovery of treatment period.

Free Research Field

薬理学