TRPV4 in Postoperative Pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: Kido Kanta 東北大学, 大学病院, 助教 (40343032)
• Co-Investigator(Kenkyū-buntansha): 正木 英二 東北大学, 歯学研究科, 教授 (40221577) ; 安田 真 東北大学, 大学病院, 助教 (70431591)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 術後痛 / PAR-2 / TRPV4

Outline of Final Research Achievements

Postoperative pain is difficult to treat, despite effective postoperative analgesia, which improves patient satisfaction and decreases morbidity and mortality after surgery. To elucidate the mechanism of postoperative pain is necessary to develop new techniques. we hypothesized that: (1) incision induced the release of tryptase from mast cells or elastase from neutrophils that activate PAR-2; (2) the activation of PAR-2 sensitizes TRPV4; (3) local osmolarity changes in wounds stimulated TRPV4 and increased postoperative pain and inflammation. We finally demonstrated that osmolarity were increased in wounds for at least 48 hours after incision. In skin, TRPV4 contributed to hypersensitivity and paw edema after incision.

Free Research Field

歯科麻酔学