Development of a novel general anesthetic method applying the enhancement of descending pain suppression system: Utilization of 5-HT receptor ligands

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Irifune Masahiro 広島大学, 医歯薬保健学研究科(歯), 教授 (10176521)
• Co-Investigator(Kenkyū-buntansha): 兼松 隆 広島大学, 医歯薬保健学研究科(歯), 教授 (10264053)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: サブスタンスP / 脊髄後角組織 / イミプラミン / モルヒネ / プロポフォール / ケタミン / マイクロダイアリシス法

Outline of Final Research Achievements

Whether the selective serotonin receptor ligands inhibit or whether the general anesthetics enhance substance P (SP) release from cultured rat dorsa root ganglion (DRG) neurons or rat spinal cord chopped tissues was examined. Capsaicin increased SP release from cultured DRG cells in a concentration-dependent fashion. The intravenous general anesthetics propofol and ketamine and the opioid receptor agonist morphine did not affect the capsaicin-induced SP release. Also, capsaicin concentration-dependently increased SP release from rat spinal cord chopped tissues. Morphine concentration-dependently inhibited the capsaicin-induced SP release. High concentrations of propofol enhanced the SP release, but ketamine did not. As the selective serotonin uptake inhibitor imipramine concentration-dependently increased the SP release, this drug did not have antinociceptive action in this region.

Free Research Field

歯科麻酔学