A study of the impaired pain modulation system in the brain of BMS patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: IMAMURA Yoshiki 日本大学, 歯学部, 教授 (90176503)
• Co-Investigator(Kenkyū-buntansha): 篠崎 貴弘 日本大学, 歯学部, 講師 (50339230) ; 岩田 幸一 日本大学, 歯学部, 教授 (60160115) ; 野間 昇 日本大学, 歯学部, 准教授 (70386100) ; 岡田 明子 日本大学, 歯学部, 准教授 (10434078)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: バーニングマウス症候群 / 機能脳科学 / fMRI / QST

Outline of Final Research Achievements

The pain modulation system in the brain of the BMS patients　was　investigated　using　quantitative　sensory　testing　and　functional　MRI　to　clarify　the　pathophysiology of BMS which is one of the most typical orofacial pain with unknown origin. In BMS patients, temporal and spatial summation is facilitated as compared to healthy controls, in which impaired pain modulation system of the brain is involved. Habituation was less significant in BMS patients when noxious heat stimulation was applied at the lower lip. BMS patients report pain reduction after gum chewing. At this moment, BMS patients showed facilitated activity of the Dorsal Attention Network and increased connectivity between the thalamus and the inferior frontal gyrus (pars opercularis).

Free Research Field

歯科麻酔学