2017 Fiscal Year Final Research Report
Interdisciplinary research for elucidating mechanisms of infective endocarditis onset and development with focus on oral bacteria and host defense interactions
| Project/Area Number |
15K11363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Nomura Ryota 大阪大学, 歯学研究科, 准教授 (90437385)
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| Co-Investigator(Kenkyū-buntansha) |
仲 周平 岡山大学, 大学病院, 講師 (10589774)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口腔細菌 / 感染性心内膜炎 / コラーゲン結合タンパク（CBP） / タンパク抗原（PA） / ex vivo評価系 / ウシ心臓弁 / ラット感染性心内膜炎モデル / 血清 |
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| Outline of Final Research Achievements |
To analyze the pathogenesis of IE induced by Streptococcus mutans strains with different patterns of expression of a 120-kDa collagen-binding protein (CBP) and 190-kDa protein antigen (PA), we focused on adhesion of the bacterium to human pulp cells and its interaction with liquid components in blood. CBP-positive S. mutans strains had a high level of adhesion to human pulp cells, while CBP+/PA- strains showed aggregation in the presence of serum, which may contribute to the pathogenicity of IE.
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| Free Research Field |
歯学
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