2018 Fiscal Year Final Research Report
Elucidation of periodontitis onset mechanism based on C1q and Wnt signaling
| Project/Area Number |
15K11394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原 宜興 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 歯周ポケット形成 / 老化促進因子 / 動物モデル |
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| Outline of Final Research Achievements |
To clarify the mechanism of periodontal onset, we investigated whether C1q and wnt signaling involved in the pocket formation using a rat periodotitis model.C1q was observed in the JE and in the connective tissue around the periodontal pocket in rat. Furthermore, C1qB was localized within the junctional epithelium around the periodontal pocket in long junctional epithelium rat model. These results suggest that C1q is involved in the pocket formation.
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| Free Research Field |
歯周病学
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| Academic Significance and Societal Importance of the Research Achievements |
歯周病は日本人の7割以上が罹患している疾患であり、抜歯の原因の第一位である。その歯周炎の最大のリスクファクターである歯周ポケット形成への老化促進因子であるC1qの関与が示唆されたことは歯周ポケット形成メカニズムの解明において重要であり、ひいては歯周病の予防法や治療法の開発に強く寄与できると思われる。
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