Effects of traumatic occlusion on periodontal destruction in patients with chronic periodontitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Kyushu Dental College
• Principal Investigator: NAKASHIMA Keisuke 九州歯科大学, 歯学部, 教授 (80227785)
• Co-Investigator(Kenkyū-buntansha): 臼井 通彦 九州歯科大学, 歯学部, 准教授 (10453630)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 外傷性咬合 / 慢性歯周炎 / 歯肉溝滲出液 / サイトカイン

Outline of Final Research Achievements

The aim of this investigation was to clarity the effects of traumatic occlusion on inflammation inside periodontal pockets by measuring cytokine levels in gingival crevicular fluid (GCF) before and after occlusal adjustment. Cytokine levels in GCF obtained from 18 periodontally involved teeth at the four treatment stages (Before periodontal initial therapy, after supragingival scaling, after occlusal treatment, after scaling and root plaining) were measured. Clinical parameters (PPD, PESA and PISA) were significantly improved during periodontal initial therapy. Significant correlations were also observed between changes in clinical parameters (PPD and PESA) and changes in some cytokine levels (GM-CSF, IL-1alpha, IL-2, IL-3, IL-13, IL-15, IL-16, IP-10, RANTES, TNF-alpha, TNF-beta, sTNF-R1, sTNF-R2, PDGF-BB).

Free Research Field

歯周病学