Comprehensive analysis in oral microbiome as a promoting factor for esophageal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11408
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: TANDA NAOKO 東北大学, 大学病院, 助教 (00422121)
• Co-Investigator(Kenkyū-buntansha): 亀井 尚 東北大学, 医学系研究科, 教授 (10436115) ; 高橋 信博 東北大学, 歯学研究科, 教授 (60183852) ; 小関 健由 東北大学, 歯学研究科, 教授 (80291128) ; 鷲尾 純平 東北大学, 歯学研究科, 講師 (20400260) ; 細川 亮一 東北大学, 医学系研究科, 非常勤講師 (40547254) ; 菅崎 将樹 東北大学, 大学病院, 助教 (50444013) ; 末永 華子 東北大学, 歯学研究科, 助教 (00508939) ; 佐久間 陽子 東北大学, 歯学研究科, 助教 (90735531)
• Co-Investigator(Renkei-kenkyūsha): ITO Emi 東北大学, 歯学研究科, 技術一般職員 (80596817)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: acetaldehyde / esophageal cancer / intensive oral care

Outline of Final Research Achievements

Acetaldehyde is a powerful carcinogen in thoracic esophageal cancer. The aim of this study is to evaluate perioperative change of mouth acetaldehyde and its causal oral bacteria in thoracic esophageal cancer patients under intensive oral care. Analysis was done compared to control cases. Drinking and smoking histories were longer and oral condition was worse in patients group than in control. Acetaldehyde in mouth air of thoracic esophageal cancer patients decreased after oral intensive care before operation. It also decreased after operation. It is suggested that intensive oral care for perioperative thoracic esophageal cancer patients decreases acetaldehyde produced in oral microbiome.

Free Research Field

予防歯科 周術期口腔管理　口臭