2017 Fiscal Year Final Research Report
Relationship of taste experience and feeding behavior in weaning period of autism- spectrum-disorder-model rat
| Project/Area Number |
15K11428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大川 周治 明海大学, 歯学部, 教授 (90144865)
村本 和世 明海大学, 歯学部, 教授 (10301798)
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| Research Collaborator |
TAKANO Lisa
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 自閉症スペクトラム / 疾患モデルラット / 摂食行動 / 食餌選択性 / 離乳期 |
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| Outline of Final Research Achievements |
The aim of this study was to find out the biased food preference and support method for children with autism spectrum disorder, therefore, the model rats were used to determine the food selectivity. The ASD-model rats and healthy rats of SD rat were prepared. These rats were fed solid food from 13th to 20th postnatal day and were fed pasted food from 21st postnatal day. Additionally, other model rats and control rats were used, and fed pasted food from 13th to 20th postnatal day and solid food from 21st postnatal day.
The amount of food intake decreased when the food was changed from pasted to solid. The amount increased in control rats at an early point, however, there was a slow recovery in ASD-model rats. Moreover, the ratio of food intake of day and night time was drastically changed in ASD-model rats. Therefore, it is suggested that changes of diet form can influence the amount of food intake and feeding pattern.
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| Free Research Field |
摂食嚥下リハビリテーション学
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