Consideration of noninvasive evaluation indicators to maintain independent life for elderly

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gerontological nursing
• Research Institution: Ishikawa Prefectural Nursing University
• Principal Investigator: HASEGAWA NOBORU 石川県立看護大学, 看護学部, 教授 (10156317)
• Co-Investigator(Kenkyū-buntansha): 望月 美也子 京都文教短期大学, 食物栄養学科, 准教授 (20367858) ; 高山 成子 金城大学, 看護学部, 教授 (30163322) ; 鳥居 昭久 愛知医療学院短期大学, 理学療法学専攻, 教授 (60513182) ; 加藤 真弓 愛知医療学院短期大学, 理学療法学専攻, 准教授 (90512856) ; 清水 暢子 石川県立看護大学, 看護学部, 助教 (20722622) ; 山田 恭子 佛教大学, 保健医療技術学部, 教授 (20191314)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ビタミンＤ / 認知機能 / 身体機能

Outline of Final Research Achievements

We enrolled 23 Japanese men (age: 76.0 ) and 17 women (age: 78.3) in this study. Blood was collected and the serum 1, 25-hydroxy vitamin D (1, 25OHD) concentration was measured. Urinary 25-hydroxy vitamin D (25OHD) was measured. The cognitive (MMSE or MoCA-J) and physical function were measured objectively using the Timed UP and Go (TUG) and 4-m walking test (4MWS). In the present study, a significant positive correlation was found between urinary 25OHD/creatinine and MMSE or MoCA-J. Our results showed that urinary 25OHD might be a useful biomarker for predicting cognitive disorder. There was a significant positive correlation was found between serum 1, 25-hydroxy vitamin D and MMSE or MoCA-J and negative correlation between serum 1, 25OHD and TUG or 4MWS. A 6 month intake of a vitamin D3 significantly decreased 4MWS. These findings suggest that serum 1, 25OHD and 25OHD levels might serve as a useful index to improve cognitive and physical functional impairment.

Free Research Field

高齢看護学