2017 Fiscal Year Final Research Report
Transcription regulatory network atlas for functional ncRNA search
| Project/Area Number |
15K12139
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | バイオインフォマティクス / システム生物学 / 遺伝子ネットワーク / 発現制御 |
|---|
| Outline of Final Research Achievements |
In this research project, the purpose is to derive a probabilistic model describing the dynamics in which the regulatory relationship between the transcriptional regulatory factor and its target gene group is changed depending on the modulator from observed expression data and to identify functional ncRNAs controlling the transcriptional activity of various transcriptional regulators. As a result of applying the proposed method to simulation data and actual data, the following results were obtained. (A) Discovery of noncoding RNA that controls the oncogene MYC, and (B) development of a large-scale analysis pipeline for the comprehensive search of modulator factors, and construction of a transcriptional regulatory network atlas.
|
| Free Research Field |
バイオインフォマティクス
|
