Dietary factors and aging control: Glycosylation modified diets

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12340
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: MIYAMOTO Kenichi 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70174208)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: リン / 寿命 / 腎臓 / 食事 / klotho

Outline of Final Research Achievements

Dietary modifications such as calorie restrictions have a lifespan extension effect. Klotho deficient (KL) mice are short-lived, aged-promoted model mice. The inorganic phosphate (Pi) -restricted diet prolongs the life span of KL mice and restores its phenotype. In this study, we investigated whether Pi-restricted diet causes the modification of the N-glycosylation of Npt2c. By Pi-restricted diet, Npt2c and Klotho were induced, and the N-glycosylation pattern of Npt 2c was changed. KLNpt2c (Klotho/Npt2c DKO) mice showed the rescued KL phenotypes. In conclusion, Pi restriction was considered to be a diet inducing N-glycan modification

Free Research Field

生活科学・食生活学