Investigation of alcohol toxicity and its prevention by functional food

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12364
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Tokai University
• Principal Investigator: Nagai Ryoji 東海大学, 農学部, 教授 (20315295)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アセトアルデヒド / 翻訳後修飾 / 飲酒マーカー

Outline of Final Research Achievements

Acetaldehyde (AA), which is a metabolic intermediate of alcohol, shows toxicity by modification and denaturation of protein. In this study, AA modified amino acid was detected by LC-MS/MS in mouse serum and human serum after administration of alcohol. As this method is precise, this would be effective method to look into the association of AA and alcohol related diseases such as Alzheimer's disease and ischemic heart disease. Furthermore, we obtained monoclonal antibody against AA-modified proteins and this antibody could be useful tool to assess toxicity of AA in the near future.

Free Research Field

食品機能学・生化学