Immunosuppressive effect of novel physical medicine and identification of its receptor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12514
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kumamoto University
• Principal Investigator: Kai Hirofumi 熊本大学, 大学院生命科学研究部(薬), 教授 (30194658)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 物理療法 / アルツハイマー病 / 免疫制御

Outline of Final Research Achievements

Our laboratory has comprehensively studied the biological effects of mild electrical stimulation (MES, 0.1-ms pulse width, 55-pps) with heat shock (HS, 42℃). Specifically, MES+HS improved the inflammatory symptom in mouse models of diabetes and chronic kidney disease. To determine whether MES+HS suppresses psoriasis pathology, I used imiquimod-induced psoriasis mouse model. Notably, MES+HS (10 min, daily) significantly suppressed imiquimod-induced psoriasis-like skin hyperplasia, activation of Akt and expression of psoriasis-related genes (Krt6a, IL-17A and IL-22). Taken together, MES+HS improves psoriasis, at least in part, by suppressing the expression of cytokines．

Free Research Field

総合領域