A nanosystem as an alternative to immunoadsorption plasmapheresis and its application in the treatment of dilated cardiomyopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12531
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KANG JEONG-HUN 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50423512)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 生体制御・治療 / 生体材料 / ナノ材料

Outline of Final Research Achievements

The ultimate aim of this study is to develop a nanosystem that can remove blood immunoglobulin (IgG) and to apply the treatment of dilated cardiomyopathy. The eat-me signal phosphatidylserine was involved in nanosystems for their specific recognition by macrophage, and the protein G was grafted on the surface of nanosystems for the IgG-specific binding. The nanosystem showed high-affinity binding to macrophage cells. After intravenous injection into myocarditis model mice, nanosystems inhibited the occurrence of myocarditis and dilated cardiomyopathy.

Free Research Field

人間医工学