Characterization of tumor-derived exosomes for drug delivery

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K12550
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition
• Principal Investigator: Tsunoda Shin-ichi 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 バイオ創薬プロジェクト, プロジェクトリーダー (90357533)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: 生体機能利用 / 生体分子 / 薬学 / 癌 / exosome / EphA2

Outline of Final Research Achievements

In this study, characterization of tumor-derived exosomes were performed to collect basic knowledge useful for development of drug delivery technology. We found that lung cancer cells secreted angiogenic exosomes and in vitro tube-formation and proliferation of endothelial cells was stimulated via EphA2 on the exosomes. These data and also further investigation of metastasis-related exosomes would provide useful knowledge for active targeting and other drug delivery technologies.

Free Research Field

プロテオミクス