Development of new purification method of extracellular vesicles for cancer diagnostics

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12566
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition
• Principal Investigator: Kamada Haruhiko 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, プロジェクトリーダー (00324509)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 分泌膜小胞 / バイオマーカー / エクソソーム / アフィニティ精製カラム

Outline of Final Research Achievements

New purification method of extracellular vesicle that derived from cancer cells was developed for the development of new diagnostic technique without using the human blood. We have identified the new biomarker proteins expressed on the extracellular vesicles and have created new monolith column for the purification of extracellular vesicles. These result indicated that this method is useful for collect the extracellular vesicles and will expect to utilize for development for new diagnostic method for cancer patients.

Free Research Field

タンパク質工学