2016 Fiscal Year Final Research Report
Development of an adjuvant therapy with combination of nutrition and physical modalities for improvement of performance status in cancer cachexia
Project/Area Number |
15K12585
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Sapporo Medical University |
Principal Investigator |
Yamada Takashi 札幌医科大学, 保健医療学部, 准教授 (50583176)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 癌性カヘキシア / 筋萎縮 / グルタミン / 神経筋電気刺激 / グルココルチコイド / グルタミン合成酵素 |
Outline of Final Research Achievements |
We aimed to investigate whether the combination of glutamine (GLN) administration and neuromuscular electrical stimulation (ES) prevents cancer-induced muscle atrophy with a special focus on the role of glutamine synthetase (GS), a downstream regulator of glucocorticoid signaling. ES was performed to the left gastrocnemius (Gas) muscles every other day starting one day after injection of C-26. After 28 days of C-26 injection, the weight of Gas muscle were decreased in C-26 group. This change was accompanied by a marked increase in the expression of GS. Neither GLN administration, nor ES training, nor combination of these prevented the loss of muscle weight and increased expression levels of GS in C-26 Gas muscles. These data suggest that the combination of nutrition and physical modalities used in the present study could not prevent muscle atrophy and the activation of glucocorticoid signaling in cachectic muscles of C-26 mice.
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Free Research Field |
筋機能制御学
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