The mechanism of the onset of NASH and its prevention

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12691
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Yoshida Yasukazu 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 研究部門付 (90358333)
• Research Collaborator: UMENO Aya 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 特別研究員 (20749098)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ストレス / NASH / バイオマーカー / 疾病予防

Outline of Final Research Achievements

We have investigated the mechanism of the onset of NASH and the preventive effects of voluntary exercise against NASH by using the animal model of STAM. We have proposed oxidative stress markers of lipids, hydroxylinoleic acids (HODE) which can provide the oxidative stress mechanism in vivo. It was found that plasma levels of HODE increased by the procession of the diseases compared to the control mice. It was interesting that the triglyceride levels in plasma and liver decreased significantly by exercise while the HODE levels were not changed significantly by the exercise. In conclusion, oxidative stress was indeed involved in the onset mechanism of NASH and exercise is prominent for the alleviation of the disease.

Free Research Field

酸化ストレス