The effect of regular exercise on obesity-associated liver cancer from the aspect of gut microbiota and lipid metabolites

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12709
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Tokyo University of Science
• Principal Investigator: Ohtani Naoko 東京理科大学, 理工学部応用生物科学科, 教授 (50275195)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 運動 / がん予防 / がん微小環境

Outline of Final Research Achievements

We have previously revealed that obesity promoted hepatocellular carcinoma (HCC) development in mice treated with a chemical carcinogen. In this study, we tried to investigate whether exercise could reduce HCC development. Interestingly, we found that HCC development was attenuated in mice with regular Treadmill running. Moreover, obesity increased the level of blood deoxycholic acid (DCA), which was known to cause DNA damage, and the mice with Treadmill running showed reduced level of blood DCA, and increased expression of a bile acid transporter, oatp1a1(Organic anion transporting polypeptide 1a1) in their livers. Taken together, we suggest that a regular exercise such as running could prevent liver cholestasis, and thus obesity-associated HCC development by reducing blood DCA level.

Free Research Field

分子腫瘍生物学