Development of exosome including osteogenesis-related microRNA

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12714
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Mie University (2016-2017); Kinki University (2015)
• Principal Investigator: Itoh Tomohiro 三重大学, 生物資源学研究科, 准教授 (30435854)
• Co-Investigator(Renkei-kenkyūsha): AKAO Yukihiro 岐阜大学, 大学院連合創薬医療情報研究科, 教授 (00222505)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エクソソーム / マイクロRNA / 骨細胞 / 骨芽細胞 / 分化 / メカニカルストレス

Outline of Final Research Achievements

In this study, we demonstrated the effect of exosome (MS-Ov) released from mechanical stress-stimulated osteocyte on osteogenesis or osteoclastogenesis. The MS-Ov treatment induced osteoclast formation, but had no change in osteoblast differentiation. Moreover, MS-Ov contained miRNAs targeting osteoclastogenesis-related molecules. From these results, it was found that MS-Ov gives more priority to osteoclastogenesis than to osteogenesis.

Free Research Field

生化学，食品機能化学，骨代謝化学