2016 Fiscal Year Final Research Report
Chemical probes for long time imaging of osteoclasts function by optimization of emission wavelength and photostability
| Project/Area Number |
15K12754
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | in vivoイメージング / 蛍光プローブ / 破骨細胞 |
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| Outline of Final Research Achievements |
Chemical probes were developed for in vivo imaging of activated osteoclasts by using two-photon excitation microscopy. As fluorescent probes, rhodamine derivatives with pH-activatable property and red-shifted emission were designed and synthesized. The two-photon excitation microscopy images showed that fluorescence signals were observed at the specific regions in bone tissue in living mice.
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| Free Research Field |
ケミカルバイオロジー
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