Dymamics of a cluser of bubbles in a blood vessel

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13876
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Osaka Prefecture University
• Principal Investigator: Takahira Hiroyuki 大阪府立大学, 工学(系)研究科(研究院), 教授 (80206870)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 気泡 / 血管 / 共振振動数 / 線形振動 / 非線形振動

Outline of Final Research Achievements

The present study deals with bubble oscillations in an elastic tube to understand the bubble dynamics in a blood vessel. An analytical model for N spherical bubbles interacting with the tube wall is developed, in which the bubbles and the tube wall are represented by sources and spring-mass system, respectively. The natural frequencies for a single bubble or N bubbles in the tube are derived by linearizing the governing equations. The resonance frequencies of bubbles in various configurations are discussed. The influences of mass of the side wall per unit area, tube length, and initial bubble arrangements on the resonance frequencies are clarified. Also, behavior of acoustic liposomes (ALs), which are microbubbles coated by lipid membrane, are observed in a standing sound field of 110 kHz with a high speed video camera. The ALs reveal the surface oscillations of nth mode (n= 3, 4, 5, 6, 7) with a half period of the sound field, which are induced by the parametric excitation.

Free Research Field

流体工学