2016 Fiscal Year Final Research Report
Is genomic instability causally related to memory instability?
| Project/Area Number |
15K14306
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Btkチロシンキナーゼ |
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| Outline of Final Research Achievements |
The Tec family non-receptor-type tyrosine kinase Btk29A in Drosophila was found to induce transposon mobilization when mutated. Transposon mobilization is a major mechanism to induce genomic instability. We discovered that the Btk29A mutation also induces a decifit in courtship memory in male flies. This supports the notion that genomic instabilty and memory instability are related to each other. To obtain insights into the mechanism of action of Btk29A in these processes, we are conducting genome wide screens for phenotypic modifiers of Btk29A mutants.
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| Free Research Field |
総合生物
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