Development of neuronal birthdate tagging

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14323
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: National Institute of Genetics
• Principal Investigator: Hirata Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 誕生日タグ / トランスジェニックマウス / 新規技術 / 神経発生 / 脳科学

Outline of Final Research Achievements

Birth timing of neurons determines many characteristics in neurons and has been used for classification of neurons. This study developed transgenic mouse lines in which post-mitotic neurons can be genetically tagged in a birthdate-dependent manner. Four useful transgenic lines were selected and characterized in detail. Our results suggested that these lines can be used as powerful resource for neuronal classification and subsequent manipulation of the classified neuronal subset.

Free Research Field

神経発生学