2016 Fiscal Year Final Research Report
Involvement of microglial cells in the sleep/wake cycle
Project/Area Number |
15K14351
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Ehime University |
Principal Investigator |
Tanaka Junya 愛媛大学, 医学系研究科, 教授 (70217040)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | microglia / circadian / sleep / synapse / noradrenaline / EEG / phagocytosis / eat-me signal |
Outline of Final Research Achievements |
① Microglial cells become activated during sleeping time (light period; Zeitgeber Time (ZT0-12), while actively phagocytizing synapses. Around the waking time (dark period; ZT12-24), microglial phagocytic activity is suppressed. Consequently, amounts of synapses reduced during the light period as revealed by Western blotting.② Circadian changes in the concentration of noradrenaline caused the changes in the activity of microglial cells. Higher concentration of noradrenaline was correlated with suppressed microglial activity.③ It is likely that elimination of synapses by microglial cells causes asleep and maintain the sleep.④ Microglial cells eliminate only synapses with immunoreactivity of C3 or MFG-E8, suggesting the involvement of microglial cells during asleep in memory consolidation.
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Free Research Field |
神経科学
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