Study on the molecular basis underlying the disorder and recovery of sociality in inbred mouse strains

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14356
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo University of Science
• Principal Investigator: FURUICHI TEIICHI 東京理科大学, 理工学部応用生物科学科, 教授 (50219094)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 自閉症スペクトラム障害 / トランスクリプトーム / CAPS2 / 社会行動

Outline of Final Research Achievements

In this study, we performed comparative transcriptomic analysis of the cerebral cortex and basal ganglia between C57BL/6 and BTBR mice that show high and low sociality, respectively. The results showed the presence of some interesting genes with increased or decreased expression levels in BTBR brain compared to C57BL/6 brain. We also identified increased expression of exocytosis-related genes Stx5a and Syt6 and decreased expression of developmental disorder-related genes Mecp2 and Oxtr in the cerebellum of CAPS2 KO mice compared to the wild type mice.

Free Research Field

分子神経科学