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2016 Fiscal Year Final Research Report

A life design model using mutator mice

Research Project

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Project/Area Number 15K14368
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

YAGI Takeshi  大阪大学, 生命機能研究科, 教授 (10241241)

Co-Investigator(Renkei-kenkyūsha) UCHIMURA Arikuni  大阪大学, 大学院生命機能研究科, 助教 (20513063)
Research Collaborator HIGUCHI Mayumi  
Project Period (FY) 2015-04-01 – 2017-03-31
Keywords疾患モデル / マウス / 突然変異 / 量的形質 / DNA複製 / 生殖細胞 / ゲノム / 塩基配列
Outline of Final Research Achievements

In order to generate animal models for human diseases, we established mutator mouse strains which have high DNA replication error rates. We analyzed germline mutation rates and the long-term effects of mutation accumulation on phenotype in more than 20 generations of wild-type mice and mutator mice. We were successful to estimate the base-substitution mutation rate in C57BL/6 laboratory mice. The mutation rate in mutator mice was 17 times that in wild-type mice. As a result, we obtained phenotypes of human diseases from mutator mice.

Free Research Field

分子生物学

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Published: 2018-03-22  

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