2016 Fiscal Year Final Research Report
exSSSRs-Fc fusion decoys prevent S100A8/A9-mediated cancer metastasis.
| Project/Area Number |
15K14382
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 炎症 / がん / 転移 / S100A8/A9 / S100A8/A9受容体 |
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| Outline of Final Research Achievements |
It has been compiled growing mass of evidence that S100A8/A9 as a soil signal has significant role in cancer organ specific metastasis through the binding with diverse receptors such as TLR4 and RAGE, as soil sensors. In addition to them, we further succeeded to identify another important receptors, EMMPRIN, NPTNb; and MCAM. Hence, these novel molecules might become promising therapeutic targets. In this study, we prepared the extracellular regions of these molecules fused to the IgG-Fc for aiming longer half-life extension and evaluated the anti-metastatic effects of purified proteins on metastatic melanoma cells. The purified proteins suppressed markedly the S100A8/A9-mediated up-regulation of cancer cell metastasis via capturing the exogenous S100A8/A9. We therefore suggest that the developed biologics comes into a valuable appliance to regulate a “seed and soil” tumor metastasis.
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| Free Research Field |
腫瘍生物学、分子細胞生物学
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