Functional relationship between mRNA and divergently transcribed lncRNA

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14397
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research (2016); Sapporo Medical University (2015)
• Principal Investigator: Maruyama Reo 公益財団法人がん研究会, がん研究所, プロジェクトリーダー (60607985)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 長鎖非コードRNA

Outline of Final Research Achievements

Long non-coding RNA (lncRNA) has gained much attention due to its importance in every aspect of cellular and molecular processes. Recently, a lot of studies have reported a list of lncRNA genes whose expressions are dysregulated in cancer, however functions of these lncRNAs are largely unknown. In this study, we focused on pairs of mRNA and divergently transcribed lncRNAs in the same genomic region, and investigated whether there is a functional relationship between mRNA and divergently transcribed lncRNA. We first analyzed public and original expression dataset and finally selected one pair of mRNA and lncRNA for further functional analysis. We found that both the mRNA and the lncRNA have a function related to immune response, however at this point, we haven't have a evidence of functional relationship between them.

Free Research Field

分子腫瘍学