Mutual exclusiveness of driver oncogenes

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14412
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: KATAYAMA Ryohei 公益財団法人がん研究会, がん化学療法センター 基礎研究部, 主任研究員 (60435542)
• Co-Investigator(Renkei-kenkyūsha): FUJITA NAOYA 公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 分子標的治療 / 肺腺がん / がん遺伝子 / 相互排他性

Outline of Final Research Achievements

Along with the progress of genome sequencing with next generation sequencers, genetic abnormalities in cancer have been extensively uncovered. As the results of the comprehensive sequencing of cancer genome, it is known that driver oncogene mutation is mutually exclusive, but its reason has not been covered yet. In this study, we found that the excessively upregulate driver oncogene derived signaling induce cell death instead of cell proliferation using ROS1 fusion oncogene induced cells. We also found the key pathway and molecules which are related to trigger cell death when the driver oncogene signaling became excessive.

Free Research Field

腫瘍治療学