2016 Fiscal Year Final Research Report
Molecular mechanism underlying trans-generational genetic effect observed in Y-chromosome consomic mouse strains
| Project/Area Number |
15K14578
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Toyoyuki 国立遺伝学研究所, 系統生物研究センター, 助教 (20356257)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 遺伝学 / Ｙ染色体 / エピゲノム / 糖尿病 / 発現制御 |
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate the mechanism of trans-generational genetic effect (TGE), which was observed in B6/J-Y consomic mouse strains carrying the Y-chromosome derived from different mouse sub-species. In the beginning of this study, however, we observed unexpected large variation of metabolism-related data of the Y-consomic strains in the original B6/J genetic background. Therefore, we replaced the genetic background of the B6/J strains with that of a different B6-sub strain, B6/N, and examined whether the Y-consomic strains show TGE in the new B6/N genetic background. The result showed that TGE was reproduced irrespective of the genetic background.
Now, we plan to investigate the molecular mechanism underlying TGE using the newly established Y-consomic strains in the B6/N genetic background.
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| Free Research Field |
遺伝学
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