Novel mechanism for amelioration of insulin resistance by formation of rhythm in dietary intake.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14740
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Nihon University
• Principal Investigator: SEKI Taiichiro 日本大学, 生物資源科学部, 教授 (20187834)
• Co-Investigator(Kenkyū-buntansha): 細野 崇 日本大学, 生物資源科学部, 講師 (80445741) ; 増澤・尾崎 依 日本大学, 生物資源科学部, 助手 (70614717)
• Research Collaborator: KOJIMA Takayuki ; SEO Kiki ; OKAMOTO Atsushi ; NAKAGUCHI Natsumi ; FUNADO Rika ; OKUE Sachiko ; KUGUU Ayano
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生活習慣病 / インスリン抵抗性 / 肥満

Outline of Final Research Achievements

The amount of energy intake by Japanese people is decreasing in recent years; however, number of obese people tend to increase reciprocally. It seems that complex changes in lifestyle such as the time to eat a meal and diversified diet are causes of the increase in obesity and lifestyle related diseases. Even if we eat the same diet, the body weight gain or energy metabolism greatly differs depending on the time to eat. More obvious metabolic rhythm is formed by restricted feeding in comparison with the feeding ad libitum, and the obesity and insulin resistance are improved accordingly. In this study, we tried to elucidate the relationship between dietary content as well as timing of diet and obesity and insulin resistance from the viewpoint of chrononutrition.

Free Research Field

栄養生理化学