2017 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance
Project/Area Number |
15K14840
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Animal production science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
HAKUNO FUMIHIKO 東京大学, 大学院農学生命科学研究科, 助教 (30282700)
KATAOKA NAOYUKI 東京大学, 大学院農学生命科学研究科, 特任准教授 (60346062)
FUJII WATARU 東京大学, 大学院農学生命科学研究科, 助教 (40708161)
ITO AKIHIRO 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (40391859)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 代謝・内分泌制御 / インスリン受容体 / スプライシング / インスリン様シグナル |
Outline of Final Research Achievements |
Alternative splicing of insulin receptor (IR) of exon 11 encoding a part of the a-subunit results in the expression of two isoforms: IR-A (skipping exon 11) and IR-B (including exon 11). Our results demonstrated that alternative splicing of insulin receptor RNA is regulated in tissue-specific manners in response to environment changes through insulin receptor substrate-1, splicing regulatory factor PRMT5, and various splicing factors including RBFOX. We also found the differences of insulin-like signaling between IR-A and IR-B.
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Free Research Field |
分子内分泌学
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