Development of the new drug transmission absorption examination model by two phase culture system of intestinal epithelium cell and myofibroblast

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14855
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: Sato Koichi 山口大学, 共同獣医学部, 教授 (90205914)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 消化管上皮細胞 / 筋線維芽細胞 / 3次元培養 / 薬物透過吸収

Outline of Final Research Achievements

As for the medical supplies and the effect and the safety of functional foods done ingestion of, the result of the digestive organs transmission absorption examination that I used a cultured cell for becomes important materials in evaluation to depend on the absorption from digestive organs. However, single-layered culture system by single epithelium cell is used for the current absorption transmission examination system. That a cortex consisting of various epithelium cells in the digestive organs of the living body and myofibroblast cell arrange it right under an epithelium cell are not considered.
I this project, I establish the material transmission absorption examination system that is almost living body environment. And I offer the new evaluation method how medicine and the effectiveness and the safety of functional foods were reflected more.

Free Research Field

獣医薬理学