Pathogenesis of canine breed-specific colorectal polyps

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14863
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Nakayama Hiroyuki 東京大学, 大学院農学生命科学研究科(農学部), 教授 (40155891)
• Co-Investigator(Renkei-kenkyūsha): CHAMBERS James 東京大学, 農学生命科学研究科, 助教 (00621682) ; TSUBOI Masaya 東京大学, 農学生命科学研究科, 特任助教 (20721963)
• Research Collaborator: OHNO Koichi 東京大学, 農学生命科学研究科, 准教授 ; NAKAJIMA Kou 日本小動物医療センター, 理事(獣医師) ; NIBE Kazumi 日本動物高度医療センター, 獣医師
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 大腸ポリープ / 腺腫 / 腺癌 / ミニチュアダックスフント / ジャックラッセルテリア / 犬

Outline of Final Research Achievements

This study was conducted to elucidate the pathogenesis of canine gastrointestinal epithelial tumors. The study revealed that gastrointestinal tumors in Jack Russell Terriers can occur from a young age, thorough the stomach and rectum, suggesting some genetic background in the canine breed such as the mutation of APC gene mutation. Inflammatory polyps of the Dachshund dog breed was also considered as a breed specific diseases, and COX II and/or FGF-II may play the important role on their progression and malignant transformation. The intra-nuclear expression of Beta-catenin found frequently in the polypoid growth type of epithelial tumors, suggesting tumoregenesis via the beta-catenin/Wnt signaling pathway. Besides, the absence of beta-catenin expression in carcinomas of non-polypoid growth type, such as signet ring cell carcinomas, might indicate that the de novo carcinogenesis in which the malignant transformation occur directly from normal epithelial cells.

Free Research Field

獣医病理学