Identification of targeted antigen for the treatment of canine T cell lymphoma by using multiple immunization.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14870
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: Mizuno Takuya 山口大学, 共同獣医学部, 教授 (90398826)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 犬 / 腫瘍 / 抗体

Outline of Final Research Achievements

To establish the antibody-based therapy for canine lymphoma, the monoclonal antibodies against canine lymphoma cell lines were obtained. Among the established clones, 3 clones were deeply investigated to confirm the reactivity to canine lymphoma cell lines, tumor cells from dogs with lymphoma, and PBMC from healthy beagles. Three antibodies reacted to some of canine lymphoma cell lines, but only one antibody reacted weakly to tumor cells from lymphoma dogs, but none of antibodies reacted to PBMC from healthy beagles. Furthermore, these antibodies could not be used to stain the paraffin-embedded lymphoma tissues.

Free Research Field

獣医腫瘍学