Study on metabolic shift regulated by translation factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14925
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Matsuyama Akihisa 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (90399444)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 翻訳

Outline of Final Research Achievements

To investigate the role of hypusination, a post-translational modification specific to translation factor eIF5A, in translation, we identified several mRNA sequences whose product levels were affected by the presence or absence of hypusination. The fact that sequences whose translation require hypusination of eIF5A did not overlap with those identified as targets of eIF5A suggested that eIF5A alters target proteins according to its modification status.

Free Research Field

分子生物学